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Inflammation, Food Sensitivities, Leaky Gut, and MORE w/Brent L. Dorval, Ph.D., CSO, KBMO Diagnostic

Dr. Dorval has over 35 years’ experience in strategic management of research, manufacturing and regulatory affairs in the area of medical devices and diagnostics. Most recently, Dr. Dorval founded Brendan BioScience to capitalize on patents covering new immunoassay methods for analyte detection.

Dr. Dorval holds a Ph.D. in Medical Microbiology and Immunology from the College of Medicine, The Ohio State University and performed Postdoctoral studies and was a Visiting Scholar in the Department of Chemistry at the Massachusetts Institute of Technology. In addition, Dr. Dorval was an advisor to The World Health Organization committee on vaccines and diagnostics in Geneva.

Join Lindsay O'Neill for an in-depth discussion with Dr. Dorval on food sensitivities, inflammation, leaky gut, and what it means for you!

Quick 10 question recap:

1. Can you explain what food sensitivities are and how they differ from food allergies and food intolerance? Food sensitivity is caused by IgG and immune complexes which activate complement and are delayed reactions (>12 hours). Allergies are caused by IgE and are immediate (minutes) and can be life threatening. Intolerance is not immune mediated and can be caused by a food that causes inflammation (gliadin) or lack of an enzyme (lactase) and the net result is the person experiences symptoms that may actually mimic food sensitivity.

2. What type of test does KBMO offer and can you explain the difference between your test and other tests that are out there? KBMO offers the FIT Test which measures food sensitivity (IgG), inflammation (C3d) and gut permeability (Zonulin) in one test. Other tests measure only IgG. Still other tests measure reactions of cells to foods but do not measure an analyte.

3. Why would a provider, or when should a patient ask to use a food sensitivity test? When you/your client has: autoimmune, thyroid problems, arthritis and joint pain, brain fog, fatigue, digestive/gut problems (IBS, bloat), trouble losing weight, skin rash or irritation and other inflammatory conditions. OR - if you/your client is a performance athlete and wants to enhance performance.

4. Why is the KBMO FIT test better than the other tests? Discussed innate vs acquired immunity. Measures food sensitivity, inflammation, and gut permeability in one test - others only use one variable which may not be an efficacious measurement or indication of sensitivity, inflammation and leaky gut.

5. What is Complement (innate) and why is measuring it important? Activation of complement by the IgG sensitivity directly causes inflammation.

6. Can you explain complement and inflammation in a little more detail? Discussed the generation of inflammation by C3 and clearance of immune complexes by RBC. The effect of receptor number.

7. You also mentioned that the KBMO FIT Test measures zonulin. What is zonulin and why is it important to measure? Zonulin opens tight junctions in the gut and causes leaky gut. Once leaky gut is generated, food particles pass from the lumen of the gut into the sub-mucosa and peyer's patches. The net result is that anti-food IgG antibodies and anti-zonulin antibodies form. The result is that immune complexes form that activate complement and generate inflammation. The anti-Zonulin IgG is a stable marker of zonulin release and indicates leaky gut.

8. Do you have any clinical data that supports the use of the FIT Test? Reviewed a retrospective study that looks at food sensitivities and also a study that looked at Irritable bowel syndrome.

9. What type of samples do you need, and how can I order them? Serum or DBS (fingerstick). As a provider, you can sign up for an account through Small Hinges ( - OR - if you are a patient, you can come to the Advanced Surgeon's office in Valhalla, NY - Small Hinges Office/Partner, or order a fingerstick test directly to your home:

use provider code: C-11533. You can also call or email KBMO at 617-990-5741 or email: - and ask for the Small Hinges FIT test of your choosing.

If you complete the finger-stick test at home, we will provide the needle, card, and pre-addressed and stamped envelope to ensure ease and speed of receiving the sample.

10. What test should I do? What is the cost and turnaround time? We offer three different formats of the FIT Test:

  1. FIT 22 (tests the top 22 inflammatory triggers) which does not include zonulin and costs $100.00

  2. FIT 132 (tests 132 foods, additives, colorings) includes zonulin and costs $285.00*

  3. FIT 176 (tests 176 foods, additives, colorings) which includes zonulin and costs $385.00*.

*If you are enrolled in the 10 Week Small Hinges Program, you will receive $25 back/off the Fit 132 or Fit 176 tests. Learn MORE about the 10 Week Program.

The turnaround time is 7-10 days from receipt of the blood sample.

Here is a sample of Lindsay's recent FIT 176 Test...
O'neill, Lindsay FIT-176 Report 03Mar22
Download PDF • 835KB


Remember… all food reactions are not created equal so here are some simple definitions: FOOD ALLERGY: Immunologic reaction IgE-mediated. Type I hypersensitivity. FOOD SENSITIVITY: Immunologic reaction to food, Type II/III: IgA or IgG-mediated. FOOD INTOLERANCE: Non-immunologic reaction to food. E.g. Enzyme deficiency: lactose.

Follow Small Hinges @SmallHinges and KBMO @KBMODiagnostics on Instagram.

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